Stem cells. Generalities (Part II)
Abstract
Introduction: in Cuba the collection of autologous stem cells was performed by puncture of the iliac crests. To do this, it was necessary to anesthetize the patient and have an operating room with qualified personnel trained in the technique. The introduction of a simplified method allowed extending the process to all the provinces of the country.
Objective: to analize updated information about the mobilization process and the manual method for the collection and processing of the bone marrow mononuclear cells.
Method: the national and international literature on the subject was reviewed in the last 12 years, in Spanish and English, and in printed and digital formats. The search on the Internet covered several databases and the Google Scholar search engine. A structured review was prepared from the selected materials.
Development: the different modalities of hematopoietic stem cell transplantation emerged as a therapeutic alternative to the adverse effects of high doses of chemotherapy and radiotherapy in cancer patients. However, through autologous hematopoietic stem cell transplantation, it is possible to administer intense pharmacological doses to the patient with tolerable hematopoietic and organic toxicity.
Conclusions: current knowledge about the process of cell mobilization, and the manual method for the collection and processing of bone marrow mononuclear cells, open up encouraging possibilities in basic and clinical research. The exclusive properties of these cells and the simplicity of their processing make possible their use in the treatment of different diseases.
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