Adolescent with tubulointerstitial nephritis syndrome and uveitis. Case report

Authors

DOI:

https://doi.org/10.5281/zenodo.13899493

Keywords:

adolescent, cephalosporins, fever, nephritis, interstitial; uveitis

Abstract

Introduction: tubulointerstitial nephritis syndrome and idiopathic uveitis, although rare, seem to have a higher incidence than reported, more frequently in women.

Objective: to present the case of an adolescent with tubulointerstitial nephritis and uveitis syndrome.

Case presentation: 15-year-old female patient diagnosed with tubulointerstitial nephritis and uveitis, by renal biopsy. The initial symptoms were non-specific, caused by a febrile syndrome of four weeks of evolution, blurred vision, hyperemia, and pain in the left eye. Treatment with steroids was imposed with a successful response and no relapses that worsened renal function during follow-up.

Conclusions: tubulointerstitial nephritis and uveitis syndrome is a condition that requires great diagnostic insight on the part of the specialist, since it is not accompanied by specific alterations. This presentation constitutes a contribution to the dissemination and characterization of a disease where an incidence greater than that reported in the specialized literature is suspected

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Author Biographies

Héctor Santiago Montes Fong, Palma Soriano. Santiago de Cuba, Cuba.

Máster en Ciencias en Longevidad Satisfactoria”. Especialista de Primer Grado en Oftalmología. Especialista de Primer Grado en Medicina General Integral. Profesor Asistente. Policlínico Sur “Carlos Montalván”.

Alexis Rodríguez Rivero, Palma Soriano. Santiago de Cuba, Cuba.

Licenciado Optometría y Óptica. Profesor Instructor. Policlínico Sur “Carlos Montalván”.

Naglis Velia Palacios Pavó, Juan Bruno Zayas. Santiago de Cuba, Cuba.

Especialista de Primer Grado en Oftalmología. Especialista de Primer Grado en Medicina General Integral. Profesor Instructor. Hospital General Dr.

References

Cárdenas-Velázquez F, Serna-Ojeda JC, Recillas-Gispert C. Síndrome de nefritis túbulo-intersticial y uveítis (TINU) en un paciente mexicano. Reporte de un caso y revisión de la literatura. Rev. Mex. Oftalmol. [Internet]. 2012 [citado 10 May 2021];86(2):118-23. Disponible en: https://www.elsevier.es/es-revista-revista-mexicana-oftalmologia-321-pdf-X0187451912454592

Rueda-Rueda T, Sánchez-Vicente JL, Moruno-Rodríguez A, Castilla-Martino M, López-Herrero F, Contreras-Díaz M, et al. Síndrome de nefritis túbulo-intersticial y uveítis (TINU). Tratamiento con inmunosupresorea. Arch Soc Esp Oftalmol [Internet]. 2018 [citado 10 May 2021];93(1):47-51. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0365669117300321

Dobrin RS, Vernier RL, Fish AJ. Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomata and anterior uveitis. Am J Med. 1975;59(3):325–33.

Isnardi CA, Vilela A, Kuschner P, Salvo C, Vanzetti C, Zelechower V, et. al. Síndrome de Nefritis Túbulo–Intersticial Agudo asociado a Uveítis. Medicina (B. Aires) [Internet]. 2016 [citado 10 May 2021];76(6):376-78. Disponible en: http://medicinabuenosaires.com/revistas/vol76-16/n6/376-378-Med76-5-6556-Isnardi-A.pdf

Clive DM, Vanguri VK. The Syndrome of Tubulointerstitial Nephritis With Uveitis (TINU). Am. J. Kidney Dis [Internet]. 2018 [citado 10 May 2021];72(1):118-28. Disponible en: https://ajkdblog.org/wp-content/uploads/2018/07/ajkdblog_whittier-quiz-on-clive-nr.pdf

Borrego-García E, Ruíz-Sánchez A, García-Castillo L, Vinuesa-García D. Síndrome de Nefritis Tubulointersticial y Uveitis (Síndrome TINU), en el diagnóstico de Fiebre de Origen desconocido. Diálisis y Trasplante [Internet]. 2018 [citado 10 May 2021];39(1):20-2. Disponible en: https://sedyt.org/revistas/2018_39_1/4-sindrome-de-nefritis.pdf

Abed L, Merouani A, Haddad E, Benoit G, Oligny LL, Sartelet H. Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome. Nephrol Dial Transplant [Internet]. 2008 [citado 10 May 2021];23:1452-5. Disponible en: https://academic.oup.com/ndt/article/23/4/1452/1879569?login=true

Rodríguez-González F, Reyes-Rodríguez M, Hernández FF, Medina-Rivero F. Nefritis tubulointersticial y uveítis: 2 casos clínicos de pacientes hermanos y revisión de la literatura [Internet]. 2016 [citado 10 May 2021];27:90-5. Disponible en: https://sociedadcanariadeoftalmologia.com/wp-content/revista/revista-27/27sco20.pdf

Bacallao-Méndez RA, López-Marín L, Llerena-Ferrer B. Síndrome de nefritis tubulo intersticial y uveítis. Rev cubana med. [Internet]. 2016 [citado 10 May 2021];55(4):311-18. Disponible en: http://scielo.sld.cu/pdf/med/v55n4/med05416.pdf

Maestro-de la Calera M, Castro-Ramos I, Duque-González S, Caldeiro-Díaz MJ. Síndrome TINU: a propósito de un caso. Rev Electron Port Médicos.com [Internet]. 2018 [citado 10 May 2021]. Disponible en: https://www.scielo.br/j/jbn/a/B5jtw99gy8YZhxpdNLh6DKy/?lang=pt&format=html

Morlà-Novell R, Samper-Anquela M, Azemar-Mallard J. Síndrome TINU (nefritis tubulointersticial con uveítis). Rev Esp Reumatol [Internet]. 2001 [citado 10 May 2021];28(5):280-82. Disponible en: https://www.elsevier.es/es-revista-revista-espanola-reumatologia-29-pdf-13017703

Dávila-Terreros PJ, Portugal R, Alberton V, Paz MM, Besso C, Malvar A, et al. Completando el diagnóstico con los ojos del paciente. Síndrome nefritis tubulointersticial con uveítis (TINU). Rev. nefrol. dial. traspl. [Internet]. 2020 [citado 10 May 2021];40(02):146-9. Disponible en: http://www.scielo.org.ar/pdf/nefro/v40n2/2346-8548-nefro-40-02-146.pdf

Okafor LO. Hewins P. Murray PI. DennistonAK. Tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review of its epidemiology, demographics and risk factors. Orphanet J Rare Dis. [Internet]. 2017 [citado 10 May 2021];12(128):[aprox. 9 p.]. Disponible en: https://ojrd.biomedcentral.com/articles/10.1186/s13023-017-0677-2

Pinheiro MA, Rocha MB, Oliveira-Neri B, Oliveira-Parahyba I, Moura L, Costa-De Oliveira CM, et al. TINU syndrome: review of the literature and case report. J. Bras. Nefrol. [Internet]. 2016 [citado 10 May 2021];38(1):[aprox. 7 p.]. Disponible en: https://www.scielo.br/j/jbn/a/B5jtw99gy8YZhxpdNLh6DKy/?lang=en

Amaro D, Cerreño E, Steeples LR, Oliveira-Ramos S, Marques-Neve C, Leal I. Tubulointerstitial nephritis and uveitis (TINU) syndrome: a review. Br J Ophthalmol [Internet]. 2020 [citado 10 May 2021];104(6):742-47. Disponible en: https://www.researchgate.net/profile/Ines-Leal/publication/337200946_Tubulointerstitial_nephritis_and_uveitis_TINU_syndrome_A_review/links/5dcc0bc8299bf1a47b363f0c/Tubulointerstitial-nephritis-and-uveitis-TINU-syndrome-A-review.pdf

Al Qumaizi KI, Halim K, Brekeit KA. Dobrin syndrome: A case report and review of the literature. Indian J Nephrol [Internet]. 2016 [citado 10 May 2021];26(1):39–41. [citado 10 May 2021]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753740/

Kawamata M, Akimoto T , Sugase T , Otani-Takei N, Miki T, Masuda T, et al.Tubulointerstitial Nephritis and Uveitis Syndrome: Are Drugs Offenders or Bystanders? Clin Med Insights Case Rep [Internet]. 2016 [citado 10 May 2021];9:21-4. [citado 10 May 2021]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795485/pdf/ccrep-9-2016-021.pdf

Published

2022-05-08

How to Cite

1.
Montes Fong HS, Rodríguez Rivero A, Palacios Pavó NV. Adolescent with tubulointerstitial nephritis syndrome and uveitis. Case report. Mediciego [Internet]. 2022 May 8 [cited 2024 Nov. 27];28(1):e3271. Available from: https://revmediciego.sld.cu/index.php/mediciego/article/view/3271

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Case Report

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