Effectiveness of recombinant human erythropoietin in patients with chronic predialytic renal insufficiency
Abstract
Introduction: anemia is common in chronic kidney disease and is an independent predictor of cardiac morbidity and mortality in these patients.
Objective: to evaluate the benefits of the use of recombinant human erythropoietin in the treatment of renal anemia in patients with chronic predialytic renal failure.
Method: preexperiment was performed with pre and post test with a single group in the universe of chronic kidney patients in pre-dialysis stage (stages 3-4) with anemia of renal cause, attended at the General Provincial Teaching Hospital of Ciego de Ávila (67 patients). The study was carried out in the period from October 2014 to September 2015. It was limited to the four municipalities of the southern territory of the province. The Friedman test was used to search for association between variables of related samples.
Results: women between 60-79 years, hypertension and diabetes mellitus as causes predominated. The 91,0 % increased hemoglobin in the range 105-125 g/L and only 8,6 % maintained higher values. Chronic kidney disease did not progress and 49,0 % reduced the left ventricle mass index. The mean dose of EPOrHu administered was 4 377 IU/week and did not vary significantly during the trial.
Conclusions: there was a significant increase in the mean values of hemoglobin and hematocrit after treatment with recombinant human erythropoietin. There were no changes in the disease, but there was improvement in left ventricular function, with an adequate haematological response with a weekly average dose less than 8 000 IU/kgDownloads
Published
How to Cite
Issue
Section
License
Those authors who have publications with this journal accept the following terms of the License CC Attribution-NonCommercial 4.0 International (CC BY-NC 4.0):
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes .
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
