Temporal situation and projection of acute diarrheal diseases: comparative analysis pre and post-COVID-19

Authors

Keywords:

COVID-19; dysentery; pediatrics; time series studies

Abstract

Introduction: Acute diarrheal disease is a significant cause of pediatric morbidity, the dynamics of which can be affected by disruptive situations such as the COVID-19 pandemic. Evaluating temporal changes and projecting trends is essential for health surveillance and management.

 

Objective: to describe the temporal situation of acute diarrheal diseases and their trend until 2029 in the pediatric population.

Methods: an interrupted time series study was conducted at the “Leonor Pérez” Pediatric Hospital from 2010 to 2024. The sample was non-probabilistic and based on convenience sampling, including 15,995 patients with a clinical diagnosis of acute diarrheal disease: 12,835 from 2010–2019 (pre-COVID) and 3,160 from 2022–2024 (post-COVID). The variables analyzed were: number of cases and time. The stages were compared using Standard Time Latency (SLT) decomposition of trend and seasonality and Local Estimated Scatter Plot Smoothing (LOESS) regression. Density curves and monthly medians were used to assess the seasonal pattern. Autoregressive integrated moving average (ARIMA) models were used to estimate the counterfactual for 2020–2021 and project the trend for 2025–2029.

Results: following the pandemic, an increase in the number of consultations for acute diarrheal disease and seasonality were observed, with sharper peaks in June and October. Residuals showed greater dispersion due to unmodeled factors. Projections using ARIMA models up to 2029 suggested a sustained upward trend in the demand for consultations, with typical seasonal fluctuations.

Conclusions: COVID-19 caused a disruption in the epidemiological dynamics of acute diarrheal disease, with a post-pandemic increase and more pronounced seasonality. Projections indicate a steadily increasing demand in the coming years

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Author Biographies

Ana Maris Alfonso Albarrán, Instituto Nacional de Higiene, Epidemiología y Microbiología. La Habana, Cuba.

Especialista de Primer Grado en Medicina General Integral y en Bioestadística. 

Darily Losada Gandarilla , Hospital Pediátrico "Leonor Pérez". La Habana, Cuba.

Especialista de Primer Grado en Estomatología General Integral y en Bioestadística.

Sara Pitti Rondan, Hospital Pediátrico “Leonor Pérez”. La Habana, Cuba.

Especialista de Primer Grado en Medicina General Integral.

Vilmania Cuenca Argote, Hospital Pediátrico “Leonor Pérez”. La Habana, Cuba.

Especialista de Primer Grado en Medicina General Integral. 

Maritza Gilda Leyva González, Aspirante a Investigador. Policlínico “Tomás Romay”. La Habana, Cuba.

Especialista de Primer Grado en Pediatría. Profesor Asistente. 

Gloria Lázara Gainza Bello, Hospital Pediátrico “Leonor Pérez”. La Habana, Cuba.

Especialista de Primer Grado en Estomatología General Integral y en Bioestadística. 

References

1. Osman M, Kassem II, Dabboussi F, Cummings KJ, Hamze M. The indelible toll of enteric pathogens: prevalence, clinical characterization, and seasonal trends in patients with acute community-acquired diarrhea in disenfranchised communities. PLoS One [Internet]. 2023 [citado 22 Ago 2025];18(3):e0282844. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC10010529/pdf/pone.0282844.pdf

2. Organización Mundial de la Salud. Enfermedades diarreicas. Datos y cifras [Internet]. Ginebra: OMS; 2024 [actualizado 7 Mar 2024; citado 10 Mar 2025]. Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/diarrhoeal-disease

3. Levine AC, Barry MA, Gainey M, Nasrin S, Qu K, Schmid CH, et al. Derivation of the first clinical diagnostic models for dehydration severity in patients over five years with acute diarrhea. PloS Negl Trop Dis [Internet]. 2022 [citado 22 jul 2025];15(3):e0011026. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC7984611/pdf/pntd.0009266.pdf

4. Rodríguez-Puga R. Incidencia y factores de riesgo de la enfermedad diarreica aguda grave en pacientes pediátricos. Rev Ciencias Médicas [Internet]. Dic 2023 [citado 22 Ago 2025];27(6):e6111. Disponible en: http://scielo.sld.cu/pdf/rpr/v27n6/1561-3194-rpr-27-06-e6111.pdf

5. Kruizinga MD, Peeters D, van Veen M, van Houten M, Wieringa J, Noordzij JG, et al. The impact of lockdown on pediatric ED visits and hospital admissions during the COVID-19 pandemic: a multicenter analysis and review of the literature. Eur J Pediatr [Internet]. 2021 [citado 20 May 2025];180(7):2271-79. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC7959585/pdf/431_2021_Article_4015.pdf

6. Ciacchini B, Tonioli F, Marciano C, Faticato MG, Borali E, Pini Prato A, et al. Reluctance to seek pediatric care during the COVID-19 pandemic and the risks of delayed diagnosis. Ital J Pediatr [Internet]. 2020 [citado 20 May 2025];46(1):87. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC7322712/pdf/13052_2020_Article_849.pdf

7. Feng L, Zhang T, Wang Q, Xie Y, Peng Z, Zheng J, et al. Impact of COVID-19 outbreaks and interventions on influenza in China and the United States. Nat Commun [Internet]. 2021 [citado 20 May 2025];12(3249):1-8. Disponible en: https://www.nature.com/articles/s41467-021-23440-1.pdf

8. Jia W, Zhang X, Sun R, Li P, Zhen X, Li Y, et al. Changes in the epidemiological characteristics of influenza in children in Zhengzhou, China, in the post-COVID-19 era. BMC Public Health [Internet]. 2024 [citado 20 Jun 2025];24(1):1938. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC11264675/pdf/12889_2024_Article_19460.pdf

9. Hyndman RJ, Rostami-Tabar B. Forecasting interrupted time series. J Oper Res Soc [Internet]. 2024 [citado 20 Jun 2025];76(4):790-803. Disponible en: https://researchmgt.monash.edu/ws/portalfiles/portal/685294608/622348660-oa.pdf

10. Hyndman RJ, Khandakar Y. Automatic time series forecasting: the forecast package for R. J Stat Softw [Internet]. 2008 [citado 20 Jun 2025];27(3):1-22. Disponible en: http://cran-r.c3sl.ufpr.br/web/packages/forecast/vignettes/JSS2008.pdf

11. Tomov L, Chervenkov L, Miteva DG, Batselova H, Velikova T. Applications of time series analysis in epidemiology: literature review and our experience during COVID-19 pandemic. World J Clin Cases [Internet]. 2023 [citado 20 Jun 2025];11(29):6974-83. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC10631421/pdf/WJCC-11-6974.pdf

12. Schaffer AL, Dobbins TA, Pearson SA. Interrupted time series analysis using autoregressive integrated moving average (ARIMA) models: a guide for evaluating large-scale health interventions. BMC Med Res Methodol [Internet]. 2021 [citado 20 jun 2025];21(58):1-12. Disponible en: https://link.springer.com/content/pdf/10.1186/s12874-021-01235-8.pdf

13. Asociación Médica Mundial. Declaración de Helsinki de la AMM. Principios éticos para las investigaciones médicas en seres humanos. Ratificada en la 75th WMA General Assembly, Helsinki, Finland, october 2024 [Internet]. Helsinki: 18ª Asamblea Mundial; 1964 [citado 29 Oct 2024]. Disponible en: https://www.wma.net/policies-post/wma-declaration-of-helsinki/

14. Cho HJ, Rhee JE, Kang D, Choi EH, Lee NJ, Woo S, et al. Epidemiology of respiratory viruses in Korean children before and after the COVID-19 pandemic: a prospective study from national surveillance system. J Korean Med Sci [Internet]. 2024 [citado 11 Jun 2025];39(19):e171. Disponible en: https://pdfs.semanticscholar.org/3be6/9e887946e0df844b89d9a15e99cf0e63cd01.pdf

15. Astutik E, Husnina Z, Yamani LN, Wangdi K. Temporal variations and spatial clusters of diarrheal diseases before and during the COVID-19 pandemic in Jakarta province, Indonesia. BMC Public Health [Internet]. Nov 2025 [citado 10 Dic 2025];25(4166):1-15. Disponible en: https://link.springer.com/content/pdf/10.1186/s12889-025-25055-3.pdf

16. Zhou Q, Hu J, Hu W, Li H, Lin GZ. Interrupted time series analysis using the ARIMA model of the impact of COVID-19 on the incidence rate of notifiable communicable diseases in China. BMC Infect Dis [Internet]. Jun 2023 [citado 30 Nov 2025];23(375):1-10. Disponible en: https://d-nb.info/130300156X/34

17. Negsso A, Arega B, Abdissa F, Zewdu B, Teshome A, Minda A, et al. Effect of COVID-19 pandemic on the incidence of acute diarrheal disease and pneumonia among under 5 children in Ethiopia- A database study. PLOS Glob Public Health [Internet]. Jun 2023 [citado 01 Dic 2025];3(6):e0000304. Disponible en: https://www.scienceopen.com/document_file/a7e320aa-ffc0-45aa-b538-f200c98c89ab/PubMedCentral/a7e320aa-ffc0-45aa-b538-f200c98c89ab.pdf

18. Tosepu R, Ningsi NY. Forecasting of diarrhea disease using ARIMA model in Kendari City, Southeast Sulawesi Province, Indonesia. Heliyon [Internet]. Nov 2024 [citado 12 Dic 2025];10(22):e40247. Disponible en: https://www.sciencedirect.com/science/article/pii/S2405844024162780

19. Posada-Fernández PE, Rodríguez-Viera IM, Posada-Rodríguez PE, Sánchez-Rojas OL. Estacionalidad y tendencia de las atenciones médicas por enfermedades diarreicas agudas en la provincia de Ciego de Ávila. Mediciego [Internet]. 2011 [citado 22 Ago 2025];17(2):[aprox. 6 p.]. Disponible en: https://revmediciego.sld.cu/index.php/mediciego/article/view/1959/2804

20. Zambrana JV, Bustos-Carrillo FA, Ojeda S, Lopez-Mercado B, Latta K, Schiller A, et al. Epidemiologic features of acute pediatric diarrhea in Managua, Nicaragua, from 2011 to 2019. Am J Trop Med Hyg [Internet]. 2022 [citado 22 Ago 2025];106(6):1757-64. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC9209918/pdf/tpmd210793.pdf

21. Li R, Lai Y, Feng C, Dev R, Wang Y, Hao Y. Diarrhea in under five-year-old children in Nepal: a spatiotemporal analysis based on demographc and health survey data. Int J Environ Res Public Health [Internet]. 2020 [citado 22 Ago 2025];17(6):2140. Disponible en: https://www.mdpi.com/1660-4601/17/6/2140

22. Haque F, Lampe FC, Hajat S, Stavrianaki K, Hasan SMT, Faruque ASG, et al. Impacts of climate change on diarrhoeal disease hospitalisations: how do the global warming targets of 1.5–2°C affect Dhaka, Bangladesh? PLoS Negl Trop Dis [Internet]. 2024 [citado 22 Ago 2025];18(9):e0012139. Disponible en: https://www.scienceopen.com/document_file/862ea0ff-f8b2-487a-9537-5a3f10c4fb02/PubMedCentral/862ea0ff-f8b2-487a-9537-5a3f10c4fb02.pdf

23. Organización Panamericana de la Salud. Rotavirus [Internet]. 2021 [citado 22 Ago 2025]. Disponible en: https://www.paho.org/es/temas/rotavirus

24. Ghoshal V, Das RR, Nayak MK, Singh S, Das P, Mohakud NK. Climatic parameters and rotavirus diarrhea among hospitalized children: a study of eastern India. Front Pediatr [Internet]. 2020 [citado 22 Ago 2025];8:573448. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC7661789/pdf/fped-08-573448.pdf

25. González-Benítez N, Miranda-Sierra CA, Cruz-Rodríguez E, Roig-Contreras CD, Rodríguez-Ortega M. Factor bayesiano para estimar la presencia de diarreas en niños por rotavirus frente a condiciones climáticas. Ecuadorian Journal of Science, Research and Innovation [Internet]. 2021 [citado 22 Ago 2025];5(2):1-15. Disponible en: https://journals.gdeon.org/index.php/esj/article/view/54/123

26. Nie J, Huang T, Sun Y, Peng Z, Dong W, Chen J, et al. Influence of the Enterovirus 71 vaccine and the COVID-19 pandemic on hand, foot, and mouth disease in China based on counterfactual models: observational study. JMIR Public Health Surveill [Internet]. 2024 [citado 22 Ago 2025];10:e63146. Disponible en: http://ingentium-kb4.s3.amazonaws.com/charisma-references/covkb/pdf/239399.pdf

27. Zhao T, Liu H, Bulloch G, Jiang Z, Cao Z, Wu Z. The influence of the COVID-19 pandemic on identifying HIV/AIDS cases in China: an interrupted time series study. Lancet Reg Health West Pac [Internet]. 2023 [citado 22 Ago 2025];36:100755. Disponible en: https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10072954&blobtype=pdf

28. Liu J, Zeng W, Zhuo C, Liu Y, Zhu L, Zou G. Impact of the COVID-19 pandemic on the incidence of notifiable infectious diseases in China based on SARIMA models between 2013 and 2021. J Epidemiol Glob Health [Internet]. 2024 [citado 22 Ago 2025];14(3):1191-201. Disponible en: https://link.springer.com/content/pdf/10.1007/s44197-024-00273-x.pdf

29. Liang D, Wang L, Liu S, Zhou X, Xia Y, Zhong P. Global Incidence of Diarrheal Diseases—An Update Using an Interpretable Predictive Model Based on XGBoost and SHAP: A Systematic Analysis. Nutrients [Internet]. 2024 [citado 22 Ago 2025];16(18):3217. Disponible en: https://www.mdpi.com/2072-6643/16/18/3217

Published

2026-02-23

How to Cite

1.
Alfonso Albarrán AM, Losada Gandarilla D, Pitti Rondan S, Cuenca Argote V, Leyva González MG, Gainza Bello GL. Temporal situation and projection of acute diarrheal diseases: comparative analysis pre and post-COVID-19. Mediciego [Internet]. 2026 Feb. 23 [cited 2026 Mar. 20];32:e4237. Available from: https://revmediciego.sld.cu/index.php/mediciego/article/view/4237

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Original article