Ethical considerations on ionizing radiation and radiological protection in relation to nuclear cardiology

Authors

DOI:

https://doi.org/10.5281/zenodo.12706655

Keywords:

ionizing radiation, medical ethics, myocardial perfusion imaging, radiation effects, shielding against radiation

Abstract

Introduction: patients and healthcare personnel are exposed daily to ionizing radiation, from which they must be protected. In practice, radiation protection involves ethical aspects that cannot be ignored by both.

Objective: to describe some ethical aspects of the use of ionizing radiation and radiological protection in nuclear medicine, with emphasis on the specialty of cardiology.

Methods: a review in the PubMed, Medline, SciELO and LILACS databases was carried out using keywords and DeCS/MeSh terms. Forty-three articles in Spanish and English were selected (26 reviews, nine original articles, and eight articles with recommendations or clinical practice guidelines). Those that presented basic concepts, ethical foundations, and analysis on radiological protection were chosen, most of them from the cardiology specialty.

Development: radiation protection emerged as a medical field due to the frequent use of ionizing radiation and the recognition of its side effects on patients and healthcare personnel. It is therefore based on bioethics. Indications for nuclear cardiology studies must be based on their risks and benefits, respect for the dignity of people, and prudence in thought and action.

Conclusions: radiological protection and its ethical aspects are inherent to the use of ionizing radiation in medical studies or treatments. In the specialty of cardiology, frequent nuclear imaging examinationsand medical procedures entails radiological risks for patients and healthcare personnel. Therefore, decisions must be based on the basic bioethical principles of justification, optimization, and limitation

Downloads

Download data is not yet available.

Author Biographies

Denia Bonilla Padron, Hospital Clínico Quirúrgico “Hermanos Ameijeiras”. La Habana

Máster en Investigación en Aterosclerosis. Profesor Instructor. Investigador Agregado. Especialista de Primer Grado en Cardiología.

Roberto León Castillo, Hospital Clínico Quirúrgico “Hermanos Ameijeiras”. La Habana

Doctor en Ciencias Médicas. Especialista de Segundo Grado en Neurología. Investigador Titular. Académico Titular. Profesor Asistente.

Lissette Mejías Pérez, Hospital Clínico Quirúrgico “Hermanos Ameijeiras”. La Habana

Especialista de Primer Grado en Medicina General Integral e Imagenología. Profesor Asistente. Investigador Agregado.

References

Puerta-Ortiz JA, Morales-Aramburo J. Efectos biológicos de las radiaciones ionizantes. RevColombCardiol [Internet]. Mar 2020 [citado 12 Abr 2024];27Sup 1:61-71. Disponible en: https://rccardiologia.com/previos/RCC%202020%20Vol.%2027/RCC_2020_27_S1/RCC_2020_27_S1_061-071.pdf

Verfaillie G, Franck C, De Crop A, Beels L, D’Asseler Y, Bacher K. A systematic review and meta-analysis on the radiation dose of computed tomography in hybrid nuclear medicine imaging. EJNMMI Phys [Internet]. Dic 2023 [citado 12 Abr 2024];10(1):32. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212852/pdf/40658_2023_Article_553.pdf

Kozuma K, Chikamori T, Hashimoto J, Honye J, Ikeda T, Ishiwata S, et al. JCS 2021 Guideline on radiation safety in cardiology. Circ J [Internet]. 2022 [citado 12 Abr 2024];86(7):1148-203. Disponible en: https://www.jstage.jst.go.jp/article/circj/86/7/86_CJ-21-0379/_pdf/-char/en

Cousins C, Miller DL, Bernardi G, Rehani MM, Schofield P, Vañó E, et al. ICRP Publication 120: Radiological protection in cardiology. Ann ICRP [Internet]. Feb 2013 [citado 12 Abr 2024];42(1):1-125. Disponible en: https://journals.sagepub.com/doi/pdf/10.1016/j.icrp.2012.09.001

Hirschfeld CB, Dondi M, Pascual TNB, Mercuri M, Vitola J, Karthikeyan G, et al. Worldwide diagnostic reference levels for single-photon emission computed tomography myocardial perfusion imaging: findings from INCAPS. JACC J [Internet]. Mar 2021 [citado 12 Abr 2024];14(3):657-65. Disponible en: https://www.sciencedirect.com/science/article/pii/S1936878X20306057

Sharkey AR, Gambhir P, Saraskani S, Walker R, Hajilou A, Bassett P, et al. Occupational radiation exposure in doctors: an analysis of exposure rates over 25 years. Br J Radiol [Internet]. Nov 2021 [cited 2024 Feb 16];94(1127):20210602. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553192/pdf/bjr.20210602.pdf

Al-Mallah MH, Bateman TM, Branch KR, Crean A, Gingold EL, Thompson RC, et al. 2022 ASNC/AAPM/SCCT/SNMMI guideline for the use of CT in hybrid nuclear/CT cardiac imaging. J NuclCardiol [Internet]. Dic 2022 [citado 12 Abr 2024];29(6):3491-535. Disponible en: https://www.sciencedirect.com/science/article/pii/S1071358123007274/pdfft?md5=48370c40bc48214efa1196404b5f1f99&pid=1-s2.0-S1071358123007274-main.pdf

Vitola JV, Mut F, Alexánderson E, Pascual TNB, Mercuri M, Karthikeyan G, et al. Opportunities for improvement on current nuclear cardiology practices and radiation exposure in Latin America: Findings from the 65-country IAEA Nuclear Cardiology Protocols cross-sectional Study (INCAPS). J NuclCardiol [Internet]. Jun 2017 [citado 12 Abr 2024];24(3):851-9. Disponible en: https://www.researchgate.net/profile/Mathew-Mercuri/publication/295681765_Opportunities_for_improvement_on_current_nuclear_cardiology_practices_and_radiation_exposure_in_Latin_America_Findings_from_the_65-country_IAEA_Nuclear_Cardiology_Protocols_cross-sectional_Study_INCAP/links/56e8036008aec65cb45e78a4/Opportunities-for-improvement-on-current-nuclear-cardiology-practices-and-radiation-exposure-in-Latin-America-Findings-from-the-65-country-IAEA-Nuclear-Cardiology-Protocols-cross-sectional-Study-INCAP.pdf

Jaschke W, Bartal G, Martin CJ, Vano E. Unintended and accidental exposures, significant dose events and trigger levels in interventional radiology. Cardiovasc Intervent Radiol [Internet]. Ago 2020 [citado 12 Abr 2024];43(8):1114-21. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369256/pdf/270_2020_Article_2517.pdf

Frane N, Bitterman A. Radiation safety and protection. En: StatPearls [Internet]. Treasure Island (FL): Stat Pearls Publishing; 2023 [citado 12 Abr 2024]. Disponible en: http://www.ncbi.nlm.nih.gov/books/NBK557499/

Bochud F, Cantone MC, Applegate K, Coffey M, Damilakis J, Del Rosario-Pérez M, et al. Ethical aspects in the use of radiation in medicine: update from ICRP Task Group 109. Ann ICRP [Internet]. Dic 2020 [citado 12 Abr 2024];49(1Supl):143-53. Disponible en: https://journals.sagepub.com/doi/pdf/10.1177/0146645320929630

Kang KW. History and organizations for radiological protection. J Korean Med Sci [Internet]. Feb 2016 [citado 12 Abr 2024];31 Supl1:S4-5. Disponible en: https://pdfs.semanticscholar.org/35f6/413fdacedca9a98cd3d010889c38e0a11908.pdf

Malone J.X-rays for medical imaging: Radiation protection, governance and ethics over 125 years. Physica Medica [Internet]. 2020 [citado 12 Abr 2024];79:47-64. Disponible en: https://www.physicamedica.com/article/S1120-1797(20)30228-3/pdf

Cho KW. Ethical foundations of the radiological protection system. Ann ICRP [Internet]. Jun 2016 [citado 12 Abr 2024];45(1Supl):297-308. Disponible en: https://journals.sagepub.com/doi/pdf/10.1177/0146645316631207

Cho KW, Cantone MC, Kurihara-Saio C, Le GuenB, Martinez N, Oughton D, et al. ICRP Publication 138: Ethical foundations of the system of radiological protection. Ann ICRP [Internet]. Feb 2018 [citado 12 Abr 2024];47(1):1-65.Disponible en: https://www.academia.edu/download/86281994/0146645317746010.pdf

Averbeck D, Candéias SM, Chandna S, Foray N, Friedl AA, Haghdoost S, et al. Establishing mechanisms affecting the individual response to ionizing radiation. Int.J.Radiat.Biol [Internet]. Mar 2020 [citado 12 Abr 2024];96(3):297-323. Disponible en: https://hal.science/hal-02431625v1/file/Establishing%20mechanisms%20affecting%20the%20individual%20response%20to%20ionizing%20radiation.pdf

Morales-Aramburo J, Puerta JA. Bases físicas de la radiación ionizante. Rev Colomb Cardiol [Internet]. Mar 2020 [citado 12 Abr 2024];27Supl 1:32-40. Disponible en: https://www.rccardiologia.com/previos/RCC%202020%20Vol.%2027/RCC_2020_27_S1/RCC_2020_27_S1_032-040.pdf

Crișan G, Moldovean-Cioroianu NS, Timaru DG, Andrieș G, Căinap C, Chiș V. Radiopharmaceuticals for PET and SPECT imaging: A literature review over the last decade. Int J Mol Sci [Internet]. May 2022 [citado 12 Abr 2024];23(9):5023. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103893/pdf/ijms-23-05023.pdf

Williams MC, Stewart C, Weir NW, Newby DE. Using radiation safely in cardiology: what imagers need to know. Heart [Internet]. May 2019 [citado 12 Abr 2024];105(10):798-806. Disponibleen:https://heart.bmj.com/content/heartjnl/105/10/798.full.pdf

Camoni L, Santos A, Attard M, Mada MO, Pietrzak AK, Rac S, et al. Best practice for the nuclear medicine technologist in CT-based attenuation correction and calcium score for nuclear cardiology. Eur J HybridImaging [Internet]. Dic 2020 [citado 12 Abr 2024];4(1):11. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218053/pdf/41824_2020_Article_80.pdf

Loose R, Wucherer M. How to measure/calculate radiation dose in patients? Cardiovasc Intervent Radiol [Internet]. Jun 2021 [citado 12 Abr 2024];44(6):835-41. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172405/pdf/270_2021_Article_2772.pdf

Munjal A, Gupta N. Radiopharmaceuticals. En: Stat Pearls [Internet]. Treasure Island (FL): Stat Pearls Publishing; 2024 [citado 12 Abr 2024]. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK554440/?report=reader

Rajaraman P, Hauptmann M, Bouffler S, Wojcik A. Human individual radiation sensitivity and prospects for prediction. Ann ICRP [Internet]. Oct 2018 [citado 12 Abr 2024];47(3-4):126-41. Disponible en: https://journals.sagepub.com/doi/pdf/10.1177/0146645318764091

Ainsbury EA, Dalke C, Hamada N, Benadjaoud MA, Chumak V, Ginjaume M, et al. Radiation-induced lens opacities: Epidemiological, clinical and experimental evidence, methodological issues, research gaps and strategy. Environ. Int. [Internet]. Ene 2021 [citado 12 Abr 2024];146:106213. Disponible en: https://www.sciencedirect.com/science/article/pii/S0160412020321681/pdfft?md5=a561accda57631ae2df4167e214bbf6a&pid=1-s2.0-S0160412020321681-main.pdf

Yamamoto Y, Minami M, Yoshida K, Nagata M, Miyata T, Yang T, et al. Irradiation accelerates plaque formation and cellular senescence in flow‐altered carotid arteries of apolipoprotein e knock‐out mice. J Am Heart Assoc [Internet]. Jul 2021 [citado 12 Abr 2024];10(14):e020712. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483483/pdf/JAH3-10-e020712.pdf

Comisión Nacional para la Protección de Sujetos Humanos de Investigación Biomédica y de Comportamiento. Informe Belmont. Principios Éticos y Directrices para la Protección de Sujetos Humanos de Investigación. Reporte de la Comisión Nacional para la Protección de Sujetos Humanos de Investigación Biomédica y de Comportamiento. [Internet]. Washington: Departamento de Salud, Educación y Bienestar de los Estados Unidos;1979 [citado 12 Abr 2024]. Disponible en: https://www.hhs.gov/sites/default/files/informe-belmont-spanish.pdf

Úbeda-De la Cerda C, Soffia-Sánchez P, Inzulza-Contardo A, Miranda-González P, Aragón-Caqueo G, Aragón-Caqueo D. Valores éticos de la protección radiológica en procedimientos de radiodiagnóstico e intervencionismo radiológico. Rev. chil. radiol. [Internet]. Dic 2021 [citado 12 Abr 2024];27(4):164-9. Disponible en: https://www.scielo.cl/pdf/rchradiol/v27n4/0717-9308-rchrad-27-4-164.pdf

Lozano-Zalce H. Ética médica e imagenología. Acta méd. Grupo Ángeles [Internet]. Feb 2017 [citado 12 Abr 2024];15(1):5-7. Disponible en: http://www.scielo.org.mx/pdf/amga/v15n1/1870-7203-amga-15-01-00005.pdf

Varkey B. Principles of clinical ethics and their application to practice. Med Princ Pract [Internet]. Feb 2021 [citado 12 Abr 2024];30(1):17-28. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923912/pdf/mpp-0030-0017.pdf

Zölzer F. Ethics of radiological protection-recent developments. J Pub Health [Internet]. Mar 2020 [citado 12 Abr 2024];42(1):183-7. Disponible en: https://academic.oup.com/jpubhealth/article-pdf/42/1/183/32650688/fdy069.pdf

Malone J, Zölzer F. Pragmatic ethical basis for radiation protection in diagnostic radiology. Br J Radiol [Internet]. Mar 2016 [citado 12 Abr 2024];89(1059):20150713. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986491/pdf/bjr.20150713.pdf

Davies EM, Bridges AJ, Chung EM. Does radiology require informed consent for radiation risk? Br J Radiol [Internet]. Nov 2021 [citado 12 Abr 2024];94(1127):20210620. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553186/pdf/bjr.20210620.pdf

Zölzer F, Zölzer N. The role of empathy in ethics of radiological protection. J Radiol Prot [Internet]. Mar 2022 [citado 12 Abr 2024];42(1):014002. Disponible en: https://iopscience.iop.org/article/10.1088/1361-6498/ac3ccb/pdf#back-to-top-target

Hirschfeld CB, Mercuri M, Pascual TNB, Karthikeyan G, Vitola JV, Mahmarian JJ, et al. Worldwide variation in the use of nuclear cardiology camera technology, reconstruction software, and imaging protocols. J Am Coll Cardiol Img [Internet]. Sep 2021 [citado 12 Abr 2024];14(9):1819-28. Disponible en: https://www.jacc.org/doi/pdf/10.1016/j.jcmg.2020.11.011?download=true

Hendel RC, Berman DS, Di Carli MF, Heidenreich PA, Henkin RE,PellikkaPA, et al. ACCF/ASNC/ACR/AHA/ASE/SCCT/SCMR/SNM 2009 appropriate use criteria for cardiac radionuclide imaging. Circulation [Internet]. Jun 2009 [citado 12 Abr 2024];119(22):e561-87. Disponible en: https://cccvi.org/wp-content/uploads/pdf/AUC-for-Cardiac-Radionuclide-Imaging.pdf

Al Badarin FJ, Spertus JA, Bateman TM, Patel KK, Burgett EV, Kennedy KF, et al. Drivers of radiation dose reduction with myocardial perfusion imaging: A large health care system experience. J Nucl Cardiol [Internet]. Jun 2020 [citado 12 Abr 2024];27(3):785-94. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669103/pdf/nihms-1520472.pdf

Srivastava MK, Pagala RM, Kendarla V, Nallapareddy K. Appropriate use criteria in myocardial perfusion imaging in a tertiary care hospital in South India: An audit. World J Nucl Med [Internet]. Sep 2020 [citado 12 Abr 2024];20(3):281-5. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488887/pdf/WJNM-20-281.pdf

Fundora-Sarraff TA, Fernández-Delgado ND, Hernández-Reyes LH, Macía-Pérez I, Medina-León MC. Ética y protección radiológica en la medicina nuclear en hematología. Rev Cubana Hematol Inmunol Hemoter [Internet]. Dic 2014 [citado 12 Abr 2024];30(4):319-31. Disponible en: http://scielo.sld.cu/pdf/hih/v30n4/hih04414.pdf

Vallejo-Venegas E. Optimización de los recursos en cardiología nuclear. Arch. Cardiol. Mex [Internet]. Jun 2003 [citado 12 Abr 2024];73(1):150-52. Disponible en: https://www.medigraphic.com/pdfs/archi/ac-2003/acs031ag.pdf

Picano E. Economic, ethical, and environmental sustainability of cardiac imaging. Eur HeartJ [Internet]. Dic 2023 [citado 12 Abr 2024];44(45):4748-51. Disponible en: https://academic.oup.com/eurheartj/article-abstract/44/45/4748/6881411?redirectedFrom=fulltext&login=true

Peix A, Mesquita CT, Gutiérrez C, Puente A, Dueñas-C KA, Massardo T, et al. Current status of nuclear cardiology practice in Latin America and the Caribbean, in the era of multimodality cardiac imaging approach: 2022 update. Nucl Med Commun [Internet]. Dic 2022 [citado 12 Abr 2024];43(12):1163-70. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645550/pdf/nmc-43-1163.pdf

Walwyn-Salas G, González-Mesa JE, Molina-Pérez D, Ramos-Machado D, López-Bejerano GM, Fernández-Gómez IM, etal. CPHR: 35 años al servicio de la protección radiológica, la salud y el medio ambiente. Nucleus [Internet]. Jun 2020 [citado 12 de abril de 2024];(67):6-13. Disponible en: http://scielo.sld.cu/pdf/nuc/n67/2075-5635-nuc-67-6.pdf

Feng A, Peña Y, Li W. Estudios cubanos sobre la técnica de perfusión miocárdica para la detección de cardiopatía isquémica. CorSalud [Internet]. Abr 2018 [citado 12 Abr 2024];10(2):138-45. Disponible en: http://scielo.sld.cu/pdf/cs/v10n2/en_cs05218.pdf

Published

2024-07-12

How to Cite

1.
Bonilla Padron D, León Castillo R, Mejías Pérez L. Ethical considerations on ionizing radiation and radiological protection in relation to nuclear cardiology. Mediciego [Internet]. 2024 Jul. 12 [cited 2024 Nov. 21];30:e3927. Available from: https://revmediciego.sld.cu/index.php/mediciego/article/view/3927

Issue

Section

Review article