Clopidogrel tablets prescription in primary health care

Authors

DOI:

https://doi.org/10.5281/zenodo.11267212

Keywords:

clopidogrel, drug interactions, myocardial ischemia

Abstract

Introduction: antiplatelets are drugs used to reduce the risk of cardiovascular events in patients with transient ischemic attack and cerebral infarction; clopidogrel is a medication widely used in some cardiovascular diseases.

Objective: to characterize the prescription of the drug clopidogrel in 75 mg tablets in a community pharmacy in the Santa Clara municipality.

Methods: a cross-sectional descriptive investigation was carried out, which corresponds to a study of the use of prescription-indication type medications in August 2023. The universe was 852 patients, who had a certified prescription for current controlled medications and the non-probabilistic sample was made up of 62 patients. The variables were analyzed: age, sex, diagnosis, comorbidities and drug interactions. The percentage was used as a summary measure of the information. The ethical principles of scientific research were complied with.

Results: the age group over 60 years predominated (77.42 %), ischemic heart disease as a diagnosis (64.52 %) and high blood pressure as a comorbidity (66.13 %). Of the patients studied, 59.68 % used four or more medications; the combination with warfarin, acetylsalicylic acid and glibenclamide were the most clinically important drug interactions.

Conclusions: the use of clopidogrel in this study is supported by the finding of the majority presence of diseases that justified its prescription in the group of 60 years or older.

Downloads

Download data is not yet available.

Author Biography

Eliezer Alemán Fernández, Farmacia Principal Municipal de Santa Clara

Licenciado en Ciencias Farmacéuticas. Farmacia Principal Municipal de Santa Clara. Villa Clara.

References

Organización Mundial de la Salud. Estadísticas Sanitarias Mundiales 2020. Monitoreando la salud para los ODS, objetivos de desarrollo sostenible [Internet]. Ginebra: Organización Mundial de la Salud; 2020 [citado 20 Ago 2023]. Disponible en: https://apps.who.int/iris/bitstream/handle/10665/338072/9789240011953spa.pdf?sequence=1&isAllowed=y%22

Hindricks G, Potpara T, Dagres N, Arbelo E, Bax J, Blomstrom-Lundqvist C, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS). Eur Heart J [Internet]. 2021 [citado 20 Ago 2023];42(5):373-498. Disponible en: https://www.escardio.org/static-file/Escardio/Guidelines/Documents/ehaa612_Suppl.pdf

United Nations, Department of Economic and Social Affairs, Population Division. World Population Ageing 2019: Highlights (ST/ESA/SER.A/430) [Internet]. Nueva York; 2019 [citado 20 Ago 2023]. Disponible en: https://digitallibrary.un.org/nanna/record/3846855/files/WorldPopulationAgeing2019-Highlights.pdf?withWatermark=0&withMetadata=0&version=1&registerDownload=1

Pantoja-Molina AD, Perilla-Orozco DM, Sánchez-Duque JA. Prescripción inapropiada en adultos mayores: Una mirada desde la atención primaria. Rev Clín Med Fam [Internet]. 2020 [citado 20 Ago 2023];13(2):171-2. Disponible en: https://scielo.isciii.es/pdf/albacete/v13n2/1699-695X-albacete-13-02-171.pdf

American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc [Internet]. 2019 [citado 20 Ago 2023];67(4):674-94. Disponible en: https://ubmm.med.buffalo.edu/uploads/MMU3/10-16-2020%20Grand%20Rounds%20-%20Beers.pdf

Núñez-Montenegro A, Montiel-Luque A, Martin-Aurioles E, García-Dillana F, Krag-Jiménez M, González-Correa JA. Evaluation of Inappropriate Prescribing in Patients Older than 65 Years in Primary Health Care. J. Clín. Med [Internet]. 2019 [citado 20 Ago 2023];8(3):E305. Disponible en: https://pdfs.semanticscholar.org/e2a8/ecba088ba280839590ba193552d12d18db19.pdf

Vélez-Gómez S, Torres I, Darío-Manrique R, Duque M, Gallo JE. Aplicación farmacogenómica de los genes CYP2C19, CYP2C9 y VKORC1 implicados en el metabolismo de los fármacos clopidogrel y warfarina. Revista Colombiana de Cardiología [Internet]. 2018 [citado 20 Ago 2023];25(6):396-404. Disponible en: http://www.scielo.org.co/pdf/rcca/v25n6/0120-5633-rcca-25-06-00396.pdf

Asociación Española de pediatría. Comité de Medicamentos. Pediamécum [Internet]. Edición 2015 [citado 20 Ago 2023]. Disponible en: https://www.aeped.es/pediamecum/generatepdf/api?n=91097

Gómez-Doblas JJ, Torres-Llergo J, Chinchurreta-Capote P, Recio-Mayoral A, Ballesteros-Prados SM, Ojeda-Pineda S, et al. Recomendaciones del manejo antiagregante en Cardiología. Documento de revisión de la Sociedad Andaluza de Cardiología. Cardiocore [Internet]. 2018 [citado 20 Ago 2023];53(4):e13-e31. Disponible en: https://www.elsevier.es/es-revista-cardiocore-298-pdf-S1889898X18300525

World Health Organization. Model List of Essential Medicines. 22 nd List [Internet]. Geneva: World Health Organization; 2021 [citado 20 Ago 2023]. Disponible en: https://syntheticdrugs.unodc.org/uploads/syntheticdrugs/res/access/pharmaceutical/selection--model-list-of-essential-medicines_html/Model_list_essential_meds_2021.pdf

Asociación Médica Mundial. Declaración de Helsinki de la AMM. Principios éticos para las investigaciones médicas en seres humanos. Ratificada en la 64ª Asamblea General, Fortaleza, Brasil, octubre 2013. Helsinki: 18ª Asamblea Mundial; 1964 [citado 20 Ago 2023]. Disponible en: http://www.anmat.gov.ar/comunicados/HELSINSKI_2013.pdf

Ministerio de Salud Pública (Cuba). Formulario Nacional de Medicamentos. [Internet]. 4ta Ed. La Habana: Ecimed; 2014 [citado 10 Ago 2023]. Disponible en: https://instituciones.sl.cu/hospmiguelenriquez/files/2018/01/Formulario-nacional-de-medicamentos.pdf

Fohtung RB, Novak E, Rich MW. Grieco FV, Spezzano A, Puzone B, et al. Effect of new oral anticoagulants on prescribing practices for atrial fibrillation in older adults. J Am Geriatr Soc [Internet]. 2017 [citado 20 Ago 2023];65:2405-12. Disponible en: https://agsjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jgs.15058

Viscogliosi I, Ettorre E, Chiriac I. Dementia correlates with anticoagulation underuse in older patients with atrial fibrillation. Archives of Gerontology and Geriatrics [Internet]. 2017 [citado 20 Ago 2023];72:108-12. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0167494316303156?via%3Dihub

Saczynski JS, Sanghai SR, Kiefe CI, Lessard D, Marino F, Waring ME. Geriatric elements and oral anticoagulant prescribing in older atrial fibrillation patients: sage-af. J Am Geriatr Soc [Internet]. 2020 [citado 20 Ago 2023];68:147-54. Disponible en: https://agsjournals.onlinelibrary.wiley.com/doi/pdf/10.1111/jgs.16178

Sánchez-Pérez H, Ramírez-Rosillo FJ, Carrillo-Esper R. Polifarmacia en el adulto mayor. Consideraciones en el perioperatorio. Rev Mex Anestesiol [Internet]. 2022 [citado 20 Ago 2023];45(1): 40-7. Disponible en: https://www.scielo.org.mx/pdf/rma/v45n1/0484-7903-rma-45-01-40.pdf

Organización Mundial de la Salud. Información general sobre la hipertensión en el mundo. Una enfermedad que mata en silencio, una crisis de salud pública mundial [Internet]. Ginebra: OMS; 2013 [citado 20 Ago 2023]:[aprox. 40 p.]. Disponible en: https://www.redalyc.org/pdf/551/55146042006.pdf

Álpizar-Cortes JE, Angeles-Lozano KL, Ávila-Ballesteros D, Luna-Calva LL, Torres-Cano WD, Olvera-Hernández EG, et al. Identificación de interacciones medicamentosas potenciales en pacientes geriátricos. JONNPR [Internet]. 2020 [citado 20 Ago 2023];5(9):998-1009. Disponible en: https://scielo.isciii.es/pdf/jonnpr/v5n9/2529-850X-jonnpr-5-09-998.pdf

Ascar GI, Hespe CB, Hernández MM. Relación entre polifarmacia y número de médicos consultados por pacientes ancianos. Revista Cubana de Farmacia [Internet]. 2015 [citado 20 Ago 2023];49(3):491-501. Disponible en: http://scielo.sld.cu/pdf/far/v49n3/far09315.pdf

Vallejos-Narváez A, Bello-Benavides A, Domínguez-Salgado MM, Cuervo-Medina MP, Fajardo-Granados DE, Quiroga-Luque CA, et al. Perfil de uso anticoagulante en pacientes hospitalizados, interacciones farmacológicas y reacciones adversas identificadas. Revista colombiana de ciencias químicas farmacéuticas [Internet]. 2020 [citado 20 Ago 2023];49(1):137-58. Disponible en: http://www.scielo.org.co/pdf/rccqf/v49n1/1909-6356-rccqf-49-01-137.pdf

Bono JO, Liberman F, Ricarte-Bratti JP. Interacciones en el tratamiento antitrombótico e hipoglucemiante. Medicina (Buenos Aires) [Internet]. 2022 [citado 20 Ago 2023];82(6):934-42. Disponible en: http://www.scielo.org.ar/pdf/medba/v82n6/1669-9106-medba-82-06-934.pdf

Chiarito M, Sanz-Sánchez J, Cannata F, Cao D, Sturla M, Panico C, et al. Monotherapy with a P2Y12 inhibitor or aspirin for secondary prevention in patients with established atherosclerosis: a systematic review and meta-analysis. Lancet [Internet]. 2020 [citado 20 Ago 2023];395:1487-95. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0140673620303159

The American Diabetes Association. 10. Cardiovascular disease and risk management: Standards of medical care in diabe¬tes-2022. Diabetes Care [Internet]. 2022 [citado 20 Ago 2023];45(Suppl 1):S144-S74. Disponible en: https://diabetesjournals.org/care/article/47/Supplement_1/S179/153957/10-Cardiovascular-Disease-and-Risk-Management

Published

2024-05-03

How to Cite

1.
Alemán Fernández E. Clopidogrel tablets prescription in primary health care. Mediciego [Internet]. 2024 May 3 [cited 2024 Nov. 21];30:e3836. Available from: https://revmediciego.sld.cu/index.php/mediciego/article/view/3836

Issue

Section

Original article