Assessment of the remdesivir use for the treatment of COVID-19
DOI:
https://doi.org/10.5281/zenodo.11492896Keywords:
antivirals, covid-19, pharmacological actions, pharmacokineticsAbstract
Introduction: remdesivir is a broad-spectrum antiviral prodrug that is used for the treatment of patients hospitalized for COVID-19.
Objective: to assess the available scientific evidence on the use of remdesivir in the treatment of COVID-19.
Methods: a review of the bibliography was carried out in the databases available in Spanish and English from the Virtual Health Library, MEDLINE, Lilacs, SciELO, EBSCO and the Google Scholar search engine from 2018 to 2021. 50 articles were selected with the needed information.
Development: therapies with nucleotide/nucleoside inhibitors directed against DNA and RNA polymerase could become the core treatments of antiviral therapy. When remdesivir is converted to an active metabolite, it causes viral RNA chain termination and inhibits viral replication, which has been confirmed in pre-clinical studies. The information available from clinical trials is controversial, however, it has been shown that it improves patient recovery time and survival. Although it has shown a favorable safety profile, adverse reactions are still being reported. The five-day treatment scheme shows good efficacy and a lower rate of interruption due to adverse effects; the inhaled route appears to improve the bioavailability of remdesivir in lung tissues.
Conclusions: remdesivir is recommended for the treatment of hospitalized patients with COVID-19 and oxygen requirements, however, more research in humans is required to confirm its clinical efficacy in these patients.
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