Kidney damage markers and progression of chronic kidney failure in the elderly
Keywords:
aged, chronic renal insufficiency, kidney function testsAbstract
Introduction: chronic renal failure is a public health problem in older adults.
Objective: to establish the possible relationship between the progression of chronic renal failure and kidney damage markers in older adults.
Methods: a prospective analytical cohort study was developed in 104 older adults from the southern territory of Ciego de Ávila, who met the inclusion criteria, between November 2017 and June 2019. The glomerular filtration rate was estimated at six, 12 and 18 months. A linear model was used for repeated measures (significance level of 95 %). The ethical principles of the investigations were complied with.
Results: at the beginning, markers of renal damage were detected in 59,62 % of the patients. At six months, 54,81 % had progression of the damage, at 12 the percentage increased to 56,73 % and at 18 to 57,69 %. No progression was seen in those with no markers detected at baseline. The relationship between the presence of the marker and the progression of the disease was demonstrated. The relationship between the presence of the marker and the progression of the disease was demonstrated. The most frequent cause was diabetes mellitus (42,31 %), and the most common complication was cardiovascular (9,62 %). Primary glomerulopathies were those with the fastest progression (9,62 %).
Conclusions: during the follow-up of the patients, the relationship between the presence of kidney damage markers and the progression of chronic kidney disease was demonstrated.Downloads
References
Boffa JJ, Cartery C. Insuficiencia renal crónica o enfermedad renal crónica. EMC Tratado de Medicina [Internet]. 2015 [citado 21 Ene 2020];19(3):E-5-0550. Disponible en: https://coek.info/download/insuficiencia-renal-cronica-o-enfermedad-renal-cronica_5af59283d64ab2aefa562e7f.html
Hill NR, Fatoba ST, Oke JL, Hirst JA, O’Callaghan CA, Lasserson DS, et al. Global prevalence of chronic kidney disease – A systematic review and meta-analysis. PloS One [Internet]. 2016 [citado 21 Ene 2020];11(7):e158765. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934905/pdf/pone.0158765.pdf
Saran R, Robinson B, Abbott KC, Agodoa LYC, Bhave N, Bragg-Gresham J, et al. US Renal Data System 2018 Annual Data Report: epidemiology of kidney disease in the United States. Am J Kidney Dis [Internet]. Mar 2018 [citado 12 Ene 2020];73(3 Supl 1):[aprox 2 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593155/pdf/nihms-1030213.pdf
Brück K, Stel VS, Gambaro G, Hallan S, Völzke H, Ärnlöv J, et al. CKD prevalence varies across the European general population. J Am Soc Nephrol [Internet]. Jul 2016 [citado 4 Ene 2020];27(7):2135-47. Disponible en: https://jasn.asnjournals.org/content/jnephrol/27/7/2135.full-text.pdf
Pérez-Oliva Díaz JF, Almaguer-López M, Herrera-Valdés R, Martínez-Machín M, Martínez-Morales M. Registro de la enfermedad renal diabética en la atención primaria de salud. Cuba, 2015. Rev haban cienc méd [Internet]. Ago 2017 [citado 23 Ene 2020];16(4):666-79. Disponible en: http://scielo.sld.cu/pdf/rhcm/v16n4/rhcm18417.pdf
Oficina Nacional de Estadísticas e Información (Cuba); Centro de Estudios de Población y Desarrollo. Estudio sobre envejecimiento poblacional en Cuba a partir del Censo de Población y Viviendas de 2012 [Internet]. La Habana: ONEI; 2014 [citado 21 Ene 2020]. Disponible en: http://www.onei.gob.cu/sites/default/files/estudio_sobre_envejecimiento_poblacional_censo_2012_0.pdf
Omuse G, Maina D, Mwangi J, Wambua C, Kanyua A, Kagotho E, et al. Comparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans: a cross sectional study. BMC Nephrol [Internet]. 2017 [citado 23 Feb 2020];18(1):369. Disponible en: https://bmcnephrol.biomedcentral.com/track/pdf/10.1186/s12882-017-0788-y.pdf
Sánchez-Román J, Castillo-Palma MJ, García-Hernández FG, González-León R. Marcadores biológicos. Utilidad para el control del paciente con hipertensión pulmonar. Arch Bronconeumol. 2011;47 Supl 7:21-5.
Lavilla-Royo FJ, Hevia-Suárez M, Pascual-Piédrola JI, Colina-Lorda I. El laboratorio en las enfermedades renales. En: Prieto-Valtueña JM, Yuste-Ara JR, editores. Balcells. La clínica y el laboratorio [Internet]. 23ra ed. Barcelona: Elsevier; 2019. p. 611-51.e5 [citado 22 Ene 2020]. Disponible en: https://doc-0o-c0-docs.googleusercontent.com/docs/securesc/navfef75vjj623arccgc5q7av6eeh60l/irqifg249a2kk55vi8fe7d2no97he6cq/1643732775000/15562948862732735853/13079244910676360518Z/1lSZZYOo-Q3rFudJKtyVfs066FvTp_p9t?e=download&nonce=e9j7bcj8n3rna&user=13079244910676360518Z&hash=614ljcv3ku85unlf5lsfcrf9vgfg6tn0
Portilla-Franco ME, Tornero-Molina F, Gil-Gregorio P. Frailty in elderly people with chronic kidney disease. Nefrología (Madr.) [Internet]. Dic 2016 [citado 11 Abr 2020];36(6):609-615. Disponible en: https://scielo.isciii.es/pdf/nefrologia/v36n6/0211-6995-nefrologia-36-06-00609.pdf
Rodríguez-Phinevy L, Garcell-Cuenca AA, Medel-Agüero MT. Diagnóstico de enfermedad renal crónica en ancianos por aclaramiento de creatinina. Hospital “Enrique Cabrera” 2016. GeroInfo [Internet]. 2017 [citado 11 Oct 2019];12(1):[aprox. 9 p.]. Disponible en: https://files.sld.cu/gericuba/files/2018/01/IRC-y-aclaramiento-creatinina.pdf
Poggio ED, Wang X, Greene T, Van Lente F, Hall PM. Performance of the modification of diet in renal disease and cockcroft-gault equations in the estimation of GFR in health and chronic kidney disease. J Am Soc Nephrol [Internet]. Feb 2005 [citado 8 Oct 2019];16(2):459-66. Disponible en: https://jasn.asnjournals.org/content/jnephrol/16/2/459.full-text.pdf
Heras M, Guerrero MT, Fernández-Reyes MJ, Sánchez R, Prado F, Álvarez-Ude F. Concordancia entre el aclaramiento de creatinina con las fórmulas MDRD y CKD-EPI para estimar el filtrado glomerular en personas de 69 años o más. Diál Traspl [Internet]. Mar 2011 [citado 12 Dic 2019];32(1):13-6. Disponible en: http://www.sedyt.org/revistas/2011_32_1/concordancia.pdf
Montañés-Bermúdez R, Bover-Sanjuán J, Oliver-Samper A, Ballarín-Castán JA, Gracia-Gacía S. Valoración de la nueva ecuación CKD-EPI para la estimación del filtrado glomerular. Nefrología (Madr.) [Internet]. 2010 [citado 12 Dic 2019];30(2):185-94. Disponible en: http://scielo.isciii.es/pdf/nefrologia/v30n2/original3.pdf
Asociación Médica Mundial. Declaración de Helsinki de la AMM. Principios éticos para las investigaciones médicas en seres humanos. Ratificada en la 64ª Asamblea General, Fortaleza, Brasil, octubre 2013. Helsinki: 18ª Asamblea Mundial; 1964 [citado 12 Dic 2019]. Disponible en: https://declaracion-de-helsinki-de-la-amm-principios-eticos-para-las-investigaciones-medicas-en-seres-humanos.pdf
Hallan SI, Dahl K, Oien CM, Grootendorst DC, Aasberg A, Holmen J, et al. Screening strategies for chronic kidney disease in the general population: follow-up of cross sectional health survey. BMJ [Internet]. 2006 [citado 12 Jun 2019];333(7585):1047-50. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1647344/pdf/bmj-333-7577-res-01047-el.pdf
Wu B, Bell K, Stanford A, Kern DM, Tunceli O, Vupputuri S, et al. Understanding CKD among patients with T2DM: prevalence, temporal trends, and treatment patterns—NHANES 2007-2012. BMJ Open Diabetes Res Care [Internet]. 2016 [citado 12 Feb 2020];4(1):000154. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838667/pdf/bmjdrc-2015-000154.pdf
Gutiérrez-Rufín M, Polanco-López C. Enfermedad renal crónica en el adulto mayor. Rev. Finlay [Internet]. Mar 2018 [citado 1 Jul 2020];8(1):[aprox 8 p.]. Disponible en: http://scielo.sld.cu/pdf/rf/v8n1/rf01108.pdf
Oficina Nacional de Estadísticas e Información (Cuba); Centro de Estudios de Población y Desarrollo. El color de la piel según el Censo de Población y Viviendas de 2012 [Internet]. La Habana: ONEI; 2016 [citado 22 Ene 2020]. Disponible en: http://www.onei.gob.cu/sites/default/files/publicacion_completa_color_de_la_piel__0.pdf
Silva-Ferrera J, Rizo-Rodríguez R, Castañeda-Márquez V, Hing-León JR. Prevalencia y causas de la insuficiencia renal crónica en 2 áreas de salud de Santiago de Cuba. MEDISAN [Internet]. Jun 2008 [citado 14 Oct 2019];12(2):[aprox. 9 p.]. Disponible en: https://www.redalyc.org/pdf/3684/368445247001.pdf
Aucella F, Corsonello A, Leosco D, Brunori G, Gesualdo L, Antonelli-Incalzi R. Beyond chronic kidney disease: the diagnosis of Renal Disease in the Elderly as an need. A position paper endorsed by Italian Society of Nephrology (SIN) and Italian Society of Geriatrics and Gerontology (SIGG). J Nephrol [Internet]. Abr 2019 [citado 21 May 2020];32(2):165-76. Disponible en: https://link.springer.com/content/pdf/10.1007/s40620-019-00584-4.pdf
Sumida K, Hoshino J, Ueno T, Mise K, Hayami N, Suwabe T, et al. Effect of proteinuria and glomerular filtration rate on renal outcome in patients with biopsy-proven benign nephrosclerosis. PLOS One [Internet]. Ene 2016 [citado 12 May 2020];11(1):e0147690. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726632/pdf/pone.0147690.pdf
Heras-Benito M, Fernández-Reyes Luis MJ. Predictores de progresión de enfermedad renal en el paciente anciano. Enferm Nefrol [Internet]. Mar 2019 [citado 12 Mar 2020];22(1):19-25. Disponible en: https://scielo.isciii.es/pdf/enefro/v22n1/2255-3517-enefro-22-01-19.pdf
Yuan J, Zou XR, Han SP, Cheng H, Wang L, Wang JW, et al. C-STRIDE study group. Prevalence and risk factors for cardiovascular disease among chronic kidney disease patients: results from the Chinese cohort study of chronic kidney disease (C-STRIDE). BMC Nephrol [Internet]. 2017 [citado 23 Jun 2020];18(1):[aprox 12 p.]. Disponible en: https://bmcnephrol.biomedcentral.com/track/pdf/10.1186/s12882-017-0441-9.pdf
Kim KS, Park SW, Cho YW, Kim SK. Higher prevalence and progression rate of chronic kidney disease in elderly patients with type 2 diabetes mellitus. Diabetes Metab J [Internet]. Jun 2018 [citado 24 Abr 2020];42(3):224-32. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015966/pdf/dmj-42-224.pdf
Candelaria-Brito JC, Gutiérrez-Gutiérrez C, Acosta-Cruz C, Casanova-Moreno MC, Montes de Oca DM. Marcadores de daño, factores de progresión y causas de Enfermedad renal crónica en adultos mayores. Rev haban cienc méd [Internet]. Oct 2019 [citado 14 Jul 2020];18(5):786-800. Disponible en: http://scielo.sld.cu/pdf/rhcm/v18n5/1729-519X-rhcm-18-05-786.pdf
Arora P, Jalal K, Gupta A, Carter RL, Lohr JW. Progression of kidney disease in elderly stage 3 and 4 chronic kidney disease patients. Int Urol Nephrol. Jun 2017;49(6):1033-400.
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