Biliary pseudolithiasis associated with the use of ceftriaxone in an adult. Case report
DOI:
https://doi.org/10.5281/zenodo.11371194Keywords:
bacterial pneumonia, CEFTRIAXONE/adverse effects, gallstonesAbstract
Introduction: vesicular pseudolithiasis is a rare complication in adults, secondary to the use of ceftriaxone. Its course is generally asymptomatic.
Objective: to present a case of biliary pseudolithiasis secondary to the use of ceftriaxone in an adult.
Case presentation: female patient, 25 years old, diagnosed with bacterial pneumonia, treated with parenteral ceftriaxone. 72 hours after starting treatment, she experienced frequent vomiting and pain in the right hypochondrium. She was prescribed therapy to control the symptoms. In the diagnostic ultrasound, microlithiasis and biliary mud were observed, which disappeared two months after stopping the antimicrobial.
Conclusions: although biliary pseudolithiasis is a rare complication in adult patients, secondary to the use of ceftriaxone, the possibility of its appearance must be anticipated to avoid aggressive therapeutic measures later.
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Aragão-Silva TF, De Araújo-Filho MA, Dos Remédios-Mendes de Brito M, Mendes-De Freitas R. Mecanismo de ação, efeitos farmacológicos e reações adversas da ceftriaxona: uma revisão de literatura. Rev Eletrôn em Farm [Internet]. 2014 [citado12 Oct 2021];11(3):48-57. Disponible en: https://revistas.ufg.br/REF/article/download/7424/17127/0
Rodríguez DA, Bustacara M, Pinilla AP, Henao L. Coledocolitiasis y colangitis como complicación del uso de ceftriaxona en niños: reporte de caso. Infect [Internet]. Sep 2012 [citado 12 Oct 2021];16(3):187-90. Disponible en: http://www.scielo.org.co/pdf/inf/v16n3/v16n3a11.pdf
Naranjo-Cárdenas EV, Novillo-Flores MC, Honores-Cabrera MJ, Cárdenas-Chávez AB. Litiasis biliar asociada a uso ceftriaxona en pediatría. Reciamud [Internet]. Jul 2022 [citado 20 Nov 2022];6(3):215-20. Disponible en: https://web.archive.org/web/20220807062428id_/https://reciamuc.com/index.php/RECIAMUC/article/download/890/1305
Bustos R, Barrientos L, Fernández P. Pseudolitiasis biliar inducida por ceftriaxona. Rev. chil. pediatr. [Internet] Ene 2001 [citado 12 Oct 2021];72(1):40-4. Disponible en: https://www.scielo.cl/scielo.php?pid=S0370-41062001000100007&script=sci_arttext&tlng=pt
Donnelly PC, Sutich RM, Easton RE, Adejumo OA, Lee TA, Logan LK. Ceftriaxone-associated biliary and cardiopulmonary adverse events in neonates: a systematic review of the literature. Paediatr Drugs. Feb 2017;19(1):21-34.
Seixas-Soares ML, Nóbrega-Lopes C, Pontes-Damaceno MM, Barbosa-De Freitas R, Ferreira-De Andrade F, Brito-De Carvalho AL, et al. Desenvolvimento de litíase biliar secundária ao uso de ceftriaxona. Braz. J. Hea. Rev. [Internet]. Jun 2020 [citado 12 Oct 2021];3(3):4687-98. Disponible en: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/download/10250/8572/26496
Cortiza-Orbe GM, González-López SL, Villamil-Martínez R, Cabrera-Machado CA, Valle-Reyes BC, Caballero-Pérez R. Guía de Práctica Clínica de litiasis vesicular en niños y adolescentes. Rev Cubana Pediatr [Internet]. Sep 2021 [citado 20 Nov 2022];93(3):e1493. Disponible en: http://scielo.sld.cu/pdf/ped/v93n3/1561-3119-ped-93-03-e1493.pdf
Rodríguez-Rangel DA, Pinilla-Orejarena AP, Bustacara-Díaz M, Henao-García L, López-Cadena A, Montoya-Camargo R, et al. Cálculos biliares asociados al uso de ceftriaxona en niños. An. pediatr. [Internet]. Feb 2014 [citado 12 de Oct 2021];80(2):77-80. Disponible en: https://analesdepediatria.org/index.php?p=revista&tipo=pdf-simple&pii=S1695403313001525
López-Milián M, Nicot-Garraway A, Neyra Y, García-Álvarez A, Alonso-Campello W, Dorzán-Rodríguez L. Litiasis vesicular asociada a la terapia con ceftriaxona. Informe de un caso. Rev inf cient [Internet] 1999 [citado 12 Oct 2021];21(1):3-13. Disponible en: https://revinfcientifica.sld.cu/index.php/ric/article/download/1721/3193
Niwa M, Tochii K. Four cases of ceftriaxone-associated biliary pseudolithiasis. J STAGE [Internet] 2016 [citado 12 Oct 2021];113(2):281-8. Disponible en: https://www.jstage.jst.go.jp/article/nisshoshi/113/2/113_281/_pdf/-char/en
Sienra MC, Pereira-Núñez D, Pacheco H, Juambeltz C. Complicaciones por pseudolitiasis vesicular y nefrolitiasis asociada a ceftriaxona. Reporte de caso. Cir Pediatr [Internet]. Jul 2020 [citado 12 Oct 2021];33(3):149-52. Disponible en: http://secipe.org/coldata/upload/revista/2020_33ESP_149.pdf
Miyamoto T, Ebihara T, Kozaki K. Ceftriaxone and pseudolithiasis in older people. Geriatr Gerontol Int. Mar 2018;18(3):507-9.
Nakajima H, Ota S, Hirose T, Hosokawa T, Ishida S, Kimura F. Ceftriaxone-associated cholelithiasis in adult patients with bacterial meningitis. J Infect Dis Ther [Internet]. 2014 [citado 12 Oct 2021];2(5):[aprox. 7 p.]. Disponible en: https://www.researchgate.net/profile/Hideto-Nakajima/publication/270901185_Ceftriaxone-associated_cholelithiasis_in_adult_patients_with_bacterial_meningitis/links/54b925850cf2c27adc491767/Ceftriaxone-associated-cholelithiasis-in-adult-patients-with-bacterial-meningitis.pdf
Yoshida R, Yoshizako T, Katsube T, Kitagaki H. Computed tomography findings of ceftriaxone-associated biliary pseudocholelithiasis in adults. Jpn J Radiol [Internet]. Dic 2019 [citado 12 Oct 2021];327(12):826-31. Disponible en: http://link.springer.com/content/pdf/10.1007/s11604-019-00893-5.pdf
Shuichi A. A case of ceftriaxone-associated biliary pseudolithiasis in a elderly patient with renal dysfunction. ID Cases [Internet]. 2017 [citado 12 Oct 2021];9:62-4. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499111/pdf/main.pdf
Narea-Falcones KA, Gaibor-Tomalá CA. Factores de riesgo que determinan el desarrollo de litiasis vesicular [Internet]. Guayaquil: Universidad de Guayaquil; 2020 [citado 12 Oct 2020]. Disponible en: https://repositorio.ug.edu.ec/server/api/core/bitstreams/e7414c4a-8d8c-4695-b390-a7720e232ead/content
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